Mitochondrial filaments and clusters as intracellular power-transmitting cables

Authors
Citation
Vp. Skulachev, Mitochondrial filaments and clusters as intracellular power-transmitting cables, TRENDS BIOC, 26(1), 2001, pp. 23-29
Citations number
45
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
26
Issue
1
Year of publication
2001
Pages
23 - 29
Database
ISI
SICI code
0968-0004(200101)26:1<23:MFACAI>2.0.ZU;2-L
Abstract
Mitochondria exist in two interconverting forms; as small isolated particle s, and as extended filaments, networks or clusters connected with intermito chondrial junctions. Extended mitochondria can represent electrically unite d systems, which can facilitate energy delivery from the cell periphery to the cell core and organize antioxidant defence of th e cell interior when O -2 is consumed by mitochondrial clusters near the outer cell membrane, and protonic potential is transmitted to the cell core mitochondria to form ATP As to small mitochondria, they might represent a transportable form of the se organelles.