PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2, 6-bisphosphate

Authors
Okar, DO Manzano, A Navarro-Sabate, A Riera, L Bartrons, R Lange, AJ
Citation
Do. Okar et al., PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2, 6-bisphosphate, TRENDS BIOC, 26(1), 2001, pp. 30-35
Citations number
52
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
26
Issue
1
Year of publication
2001
Pages
30 - 35
Database
ISI
SICI code
0968-0004(200101)26:1<30:PMABOT>2.0.ZU;2-R
Abstract
Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver,This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes, Biophysical studies of the enzyme that both synthesizes an d degrades this biofactor have yielded insight into its molecular enzymolog y, Moreover, the metabolic role of fructose-2,6-bisphosphate has great pote ntial in the treatment of diabetes.