Redox-operated genetic switches: the SoxR and OxyR transcription factors

Authors
Pomposiello, PJ Demple, B
Citation
Pj. Pomposiello et B. Demple, Redox-operated genetic switches: the SoxR and OxyR transcription factors, TRENDS BIOT, 19(3), 2001, pp. 109-114
Citations number
31
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
TRENDS IN BIOTECHNOLOGY
ISSN journal
01677799 → ACNP
Volume
19
Issue
3
Year of publication
2001
Pages
109 - 114
Database
ISI
SICI code
0167-7799(200103)19:3<109:RGSTSA>2.0.ZU;2-H
Abstract
Two redox-responsive transcription regulators have been well defined in Esc herichia coli and serve as paradigms of redox-operated genetic switches. So xR contains iron-sulfur centers that activate the protein when they are one -electron oxidized, or nitrosylated by nitric oxide. OxyR contains a pair o f redox-active cysteine residues that activate the protein when they are ox idized to form a disulfide bond.