Integrating the VEGF signals leading to actin-based motility in vascular endothelial cells

Vascular endothelial growth factor (VEGF) is a potent pro-angiogenic factor that stimulates endothelial cell proliferation and migration, two key even ts of the angiogenic process. The intracellular signals leading to these ev ent have recently been investigated and a better understanding on how VEGF induces its angiogenic functions is emerging. Herein, we summarize recent f indings on how VEGF stimulates endothelial cell migration and contributes t o angiogenesis. In particular, the role of the VEGF receptors involved in i nitiating the coordinated signals that leads to actin-based motility is dis cussed. (Trends Cardiovasc Med 2000;10:321-327). (C) 2001, Elsevier Science Inc.