Glycodelins

Glycodelin is a major glycoprotein that is synthesized in the endometrium i n response to progesterone and relaxin exposure. Endometrium-derived glycod elin-A has contraceptive and immunosuppressive properties. Glycodelin is ab sent from the endometrium during the fertile periovulatory phase, but is sy nthesized in this tissue during the peri-implantation phase and is abundant du ri ng the last week of th e luteal phase. Changes in local and/or circu lating glycodelin concentrations have been observed in women with reproduct ive disorders. The chemical modification of glycodelins has resulted in com pounds with antiviral activity.