Epigenetic analysis of kinetochore assembly on variant human centromeres

Authors
Warburton, PE
Citation
Pe. Warburton, Epigenetic analysis of kinetochore assembly on variant human centromeres, TRENDS GEN, 17(5), 2001, pp. 243-247
Citations number
27
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
01689525 → ACNP
Volume
17
Issue
5
Year of publication
2001
Pages
243 - 247
Database
ISI
SICI code
0168-9525(200105)17:5<243:EAOKAO>2.0.ZU;2-N
Abstract
Human centromere formation involves the assembly of the mitotic kinetochore onto chromosomal locations that contain the interphase prekinetochore, Imm unofluorescent analysis of two functionally converse human centromere varia nts, neocentromeres and inactive centromeres, has been used to evaluate the functional significance of over 24 centromere proteins, providing importan t insight into the epigenetics of centromere formation and kinetochore asse mbly.