Immunoregulatory role of secreted glycoprotein G from respiratory syncytial virus

Authors
Ray, R Hoft, DF Meyer, K Brown, R Lagging, LM Belshe, RB
Citation
R. Ray et al., Immunoregulatory role of secreted glycoprotein G from respiratory syncytial virus, VIRUS RES, 75(2), 2001, pp. 147-154
Citations number
29
Categorie Soggetti
Microbiology
Journal title
VIRUS RESEARCH
ISSN journal
01681702 → ACNP
Volume
75
Issue
2
Year of publication
2001
Pages
147 - 154
Database
ISI
SICI code
0168-1702(200106)75:2<147:IROSGG>2.0.ZU;2-B
Abstract
The secretory glycoplotein (Gs) of respiratory syncytial virus (RSV) was en riched and investigated for its effects on T cells specific for RSV and unr elated antigens. Gs exhibited a dose dependent suppression of lymphoprolife rative responses in peripheral blood mononuclear cells (PBMCs), specific fo r mycobacterial lysates or tetanus toroid. However, Gs did not inhibit live RSV specific T cell responses. These results suggest that Gs may suppress immune response to unrelated antigens, but should not interfere with the ov erall development of RSV specific immunity. (C) 2001 Elsevier Science B.V. All rights reserved.