ENDOTHELIN-1 - POSSIBLE IMPLICATIONS IN PULMONARY VASCULAR-DISEASE

Authors
ANGERIO AD KOT PA
Citation
Ad. Angerio et Pa. Kot, ENDOTHELIN-1 - POSSIBLE IMPLICATIONS IN PULMONARY VASCULAR-DISEASE, Heart & lung, 26(4), 1997, pp. 299-304
Citations number
41
Categorie Soggetti
Cardiac & Cardiovascular System","Respiratory System
Journal title
Heart & lung → ACNP
ISSN journal
01479563
Volume
26
Issue
4
Year of publication
1997
Pages
299 - 304
Database
ISI
SICI code
0147-9563(1997)26:4<299:E-PIIP>2.0.ZU;2-M
Abstract
The vasoactive properties of endothelin-1 (ET-1) in the animal model v ary with the tone of the pulmonary vessels, the dose level of ET-1, an d the maturation of the vessels. The action of ET-1 is mediated by end othelium-derived nitric oxide, prostaglandins, and electrolytes. Plasm a levels of ET-1 are elevated in pulmonary hypertension in both animal s and humans. ET-1 antagonists may prove useful in treating pulmonary hypertension in children and adults.