Ochrobactrum anthropi, formerly known as Achromobacter species (CDC gr
oup Vd), is an aerobic, gramnegative bacillus widely distributed in aq
uatic environments. Most important, it has been implicated as a cause
of intravenous line infection in immunocompromised hosts with solid tu
mors or hematologic malignancies. Trimethoprim-sulfamethoxazole and am
inoglycosides are usually active against O. anthropi, but this organis
m is usually resistant to beta-lactam antibiotics. Because O. anthropi
is a loss-virulence organism, patients with intravenous-line infectio
ns have been cured without removal of the intra venous catheter. We de
scribe a case of intravenous-line infection in a normal host that was
successfully resolved after catheter removal.