Experimental validation of DXA- and MRI-based determination of bone density using the ash-method

Different methods have been established for bone density measurements such as dual energy X-ray absorptiometry (DXA), quantitative computertomography (QCT), and scintigraphy. (VQ-Scan). There are hints that magnetic resonance imaging (MRI) might become a new option for the evaluation of bone density . The aim of this study was to investigate correlations between MRI vs. DXA and MRI vs. mineral content of lumbar vertebrae. Data were obtained from t en lumbar vertebral bodies of cattles. The T-l MRI-sequences SE, PS, and th e T-2 Sequence STIR were used for analysis. Total pixel numbers and a pixel per area ratio were determined. Values were compared to DXA-measurements, to the wet weight, and to separated measurements of the spongious, trabecul ar, and total mineral content of the vertebral body after asking. We found correlations between DXA (g/vertebral body) vs. mineral content by ash-meth od (0.918; p < 0.01), DXA vs. MRI (SE-sequence) (-0.872; p < 0.01), and MRI (SE-sequence) vs. mineral content (0.775; p < 0.01). No correlations were found between PS- or STIR-sequences and the ash-method. This study:shows th at the determination of the bone mineral content of vertebrae is possible a pplying MRI in the T1-weighted SE-sequence. Without radiation, the MRI prov ides additionally early detection of trabecular lesions, fractures, and def ormities at the spine, without other diagnostic procedures becoming necessa ry.