Gabapentin and gabapentin monohydrate

Authors
Ibers, JA
Citation
Ja. Ibers, Gabapentin and gabapentin monohydrate, ACT CRYST C, 57, 2001, pp. 641-643
Citations number
14
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
ISSN journal
01082701 → ACNP
Volume
57
Year of publication
2001
Part
5
Pages
641 - 643
Database
ISI
SICI code
0108-2701(200105)57:<641:GAGM>2.0.ZU;2-U
Abstract
Gabapentin [1-(aminomethyl)cyclohexaneacetic acid, C9H17NO2] is a zwitterio n in the solid state. Its crystal structure involves extensive hydrogen bon ding between the NH3+ and COO- groups of neighboring molecules. The structu re of gabapentin monohydrate [1-(aminomethyl)cyclohexaneacetic acid monohyd rate, C9H17NO2.H2O] also involves such hydrogen bonding and, in addition, h as a hydrogen-bonding network comprising the water molecules and both the N H3+ and COO- groups.