Protopine hydrochloride

Authors
Dostal, J Zak, Z Necas, M Slavik, J Potacek, M
Citation
J. Dostal et al., Protopine hydrochloride, ACT CRYST C, 57, 2001, pp. 651-652
Citations number
21
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
ISSN journal
01082701 → ACNP
Volume
57
Year of publication
2001
Part
5
Pages
651 - 652
Database
ISI
SICI code
0108-2701(200105)57:<651:PH>2.0.ZU;2-5
Abstract
Protopine hydrochloride (5,6,14,14a-tetrahydro-14a-hydroxy7-methyl-8H-bis[1 ,3]benzodioxolo[5,6-a:4,5-g]quinolizinium chloride, C20H20NO5+. Cl-) is the salt of the isoquinoline alkaloid protopine. It is formed by the action of dilute hydrochloric acid on the protopine free base. The N-methyl and hydr oxyl groups are in a trans configuration in the quinolizine ring and the ce ntral quinolizine N-C bond is unusually long [1.579 (2) Angstrom ]. The cry stal is a racemate.