This article represents the proceedings of a symposium at the 2000 ISBRA Me
eting in Yokohama, Japan. The chairs were Nobuhiro Sate and Kai O. Lindros.
The presentations were (1) Sex differences in ethanol pharmacokinetics, by
E. Baraona; (2) Estrogen regulates the sensitivity to endotoxin in hepatic
Kupffer cells, by K. Ikejima; (3) Sex difference in alcohol-related organ
injury, by E. Mezey; (4) aggravated ethanol-induced liver injury in female
rats: Protection by the antiestrogen toremifene, by Harri A. Jarvelainen; a
nd (5) Alcohol metabolism in Asian subjects: Sex differences and flushing r
esponse, by V. A. Ramchandani.