Transgenic and gene "Knockout" models in alcohol research

This article represents the proceedings of a symposium at the 2000 ISBRA Me eting in Yokohama, Japan. The chairs were Paula L. Hoffman and Takeshi Yagi . The presentations were (1) cAMP signaling in ethanol sensitivity and tole rance, by Boris Tabakoff; (2) Synaptic signaling pathways of Fyn-tyrosine k inase, by Takeshi Yagi; (3) Ethanol drinking and sensitization in dopaminer gic and serotonergic receptor knockouts, by Tamara J. Phillips; (4) ICAM-1 is involved in early alcohol-induced liver injury in the mouse given entera l alcohol, by Hiroshi Kono; and (5) Strategies for targeted and regulated k nockouts, by Robert O. Messing and Doo-Sup Choi.