This article represents the proceedings of a symposium at the 2000 ISBRA Me
eting in Yokohama, Japan. The chair was Boris Tabakoff. The presentations w
ere (1) Overview of the WHO/ISBRA study on state and trait markers in alcoh
olism, by Boris Tabakoff; (2) Biochemical markers of acute and chronic drin
king: Results of the WHO/ISBRA 2 study, by Anders Helander; (3) The impact
of country of recruitment and body mass index on biological marker dose-res
ponse curves in the WHO/ISBRA Study, by Kate M. Conigrave; (4) Relationship
of body water to carbohydrate-deficient transferrin measures, by Larry Mar
tinet; and (5) Platelet adenylyl cyclase activity as a trait marker of alco
hol dependence, by Paula L. Hoffman.