This article represents the proceedings of a symposium at the 2000 ISBRA Me
eting in Yokohama, Japan. The chairs were C. J. Peter Eriksson and Tatsushi
ge Fukunaga. The presentations were (1) 4-Methylpyrazole as a tool in the i
nvestigation of the role of ADH in the actions of alcohol in humans, by Tai
sto Sarkola and C. J. Peter Eriksson; (2)ADH2 polymorphism and flushing in
Asian populations, by Wei J. Chen, C. C. Chen, J. M. Ju, and Andrew T. A. C
heng; (3) Role of ADH3 genotypes in the acute effects of alcohol in a Finni
sh population, by Hidetaka Yamamoto, Kathrin Kohlenberg-Muller, and C. J. P
eter Eriksson; (4) Clinical characteristics and disease course of alcoholic
s with different ADH2 genotypes, by Mitsuru Kimura, Masanobu Murayama, Sach
io Matsushita, Haruo Kashima, and Susumu Higuchi; (5) ADH2 polymorphism, al
cohol drinking, and birth defects, by Lucinda Carr, D. Viljoen, L. Brooke,
T. Stewart, T. Foroud, J. Su, and Ting-Kai Li; and (6) ADH genotypes and al
cohol use in Europeans, by John B. Whitfield.