The chemistry and biological effects of malondialdehyde-acetaldehyde adducts

This article represents the proceedings of a workshop at the 2000 ISBRA Mee ting in Yokohama, Japan. The chairs were Geoffrey M. Thiele and Simon Worra ll. The presentations were (1) The chemistry of malondialdehyde-acetaldehyd e (MAA) adducts, by Dean J. Tuma; (2) The formation and clearance of MAA ad ducts in ethanol-fed rats, by Simon Worrall; (3) Immune responses to MAA ad ducts may play a role in the development of alcoholic liver disease, by Lyn ell W. Klassen; (4) Unique biological responses to MAA-modifled proteins th at may play a role in the development and/or progression of alcoholic liver disease, by Geoffrey M. Thiele; (5) MAA-adducted bovine serum albumin acti vates protein kinase C and stimulates interleukin-8 release in bovine bronc hial epithelial cells, by Todd A. Wyatt; and (6) An enzyme immune assay for serum antiacetaldehyde adduct antibody using low-density lipoprotein-adduc t and its significance in alcoholic liver injury and ALDH2 heterozygotes, b y Naruhiko Nagata.