Mechanisms of alcoholic liver disease: Cytokines

This article represents the proceedings of a workshop at the 2000 ISBRA Mee ting in Yokohama, Japan. The chair was Manuela G. Neuman. The presentations were (1) New aspects of hepatic fibrosis, by D. A. Brenner; (2) Cellular i mmune response in hepatitis C models, by B. Rehermann; (3) The role of inte rleukin-10 in acute alcoholic hepatitis, by J. Taieb, S. Ghollet-Martin, M. Cohard, J. J. Garaud, and T. Poynard; (4) Cytokine-mediated apoptosis in v itro, by M. Ci. Neuman; (5) Signaling for apoptosis and repair in vitro, by G. G. Katz, R. G. Cameron, N.H. Shear, and M. G. Neuman; (6) Interferons a ctivate the P42/44 mitogen-activated protein kinase and Janus Kinase signal transducers and activation of transcription (JAK-STAT) signaling pathways in hepatocytes: Differential regulation by acute ethanol via a protein kina se C-dependent mechanism, by B. Gao; (7) Genetic polymorphisms of interleuk in-1 in association with the development of Japanese alcoholic liver diseas e, by M. Takamatsu, M. Yamauchi, M. Ohata, S. Saito, S. Maeyama, T. Uchikos hi, and G. Toda; and (8) Increased levels of macrophage migration inhibitor y factor in sera from patients with alcoholic liver diseases, by T. Kumagi, S. M. F. Akbar, M. Abe, K. Michitaka, N. Horiike, and M. Onji.