Post-vaccination granulomas a well-known reaction due to aluminium adsorbed
vaccines. We report three cases of children who developed subcutaneous nod
ules at the site of a previous injection of Tetra-coq*vaccine (tetanus, dip
hteria, Bordetella pertussis, poliovirus). Histologically, the lesions were
chorncterized by a necrotizing granulomatous reaction with eosinophilic cr
ystalline material. This material stained positively with the solochrome cy
anine stain and was pink-purple. This aluminium stain enabled diagnosis of
post-immunization injection-site reaction due to aluminium.