Post-vaccination granuloma due to aluminium

Post-vaccination granulomas a well-known reaction due to aluminium adsorbed vaccines. We report three cases of children who developed subcutaneous nod ules at the site of a previous injection of Tetra-coq*vaccine (tetanus, dip hteria, Bordetella pertussis, poliovirus). Histologically, the lesions were chorncterized by a necrotizing granulomatous reaction with eosinophilic cr ystalline material. This material stained positively with the solochrome cy anine stain and was pink-purple. This aluminium stain enabled diagnosis of post-immunization injection-site reaction due to aluminium.