Age-related changes in the ventricular system of the dog brain

The cerebral ventricles represent cavities of the brain which are used for diagnostic purposes. Although a wide variety of age related changes have be en described in the Central Nervous System (CNS) of many species, few studi es about the effect of ageing on the canine brain have been published until now However, to date there is no previous data concerning the ventricular system of dogs. The present study deals with the morphometry of the various parts of the ce rebral cavities of the German Shepherd dog by means of Batson's casts and t he possible changes which take place in the ventricular system with age and /or sex. In this study, two age groups were considered: young (2-5 years) a nd old (10-12 years). A total number of forty seven dogs (12 young males, 1 3 old males, 13 young females and 9 old females), weighing 34-42 kg, were u sed for experimentation. Our results describe the enlargement which takes p lace in the ventricular system with age, which is probably related to a gen eral age-related atrophy of neural tissue. On the contrary, there are no re markable changes related to sex. These age-related changes are similar to t he best known changes which occur in the human species. Our data could corr oborate the usefulness of the dog as a natural animal model for the study o f normal ageing and neurodegenerative diseases.