Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa

Authors
Tateda, K Comte, R Pechere, JC Kohler, T Yamaguchi, K Van Delden, C
Citation
K. Tateda et al., Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa, ANTIM AG CH, 45(6), 2001, pp. 1930-1933
Citations number
29
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
6
Year of publication
2001
Pages
1930 - 1933
Database
ISI
SICI code
0066-4804(200106)45:6<1930:AIQSIP>2.0.ZU;2-V
Abstract
We report that 2 mug of azithromycin/ml inhibits the quorum-sensing circuit ry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducer s partially restored the expression of the trancriptional activator-encodin g genes lasR and rhlR but not that of the autoinducer synthase-encoding gen e lasI. We propose that azithromycin interferes with the synthesis of autoi nducers, by an unknown mechanism, leading to a reduction of virulence facto r production.