Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa

Authors
Aubert, D Poirel, L Chevalier, J Leotard, S Pages, JM Nordmann, P
Citation
D. Aubert et al., Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa, ANTIM AG CH, 45(6), 2001, pp. 1615-1620
Citations number
34
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
6
Year of publication
2001
Pages
1615 - 1620
Database
ISI
SICI code
0066-4804(200106)45:6<1615:ORTCAS>2.0.ZU;2-1
Abstract
Pseudomonas aeruginosa clinical isolate SOF-1 was resistant to cefepime and susceptible to ceftazidime. This resistance phenotype was explained by the expression of OXA-31, which shared 98% amino acid identity with a class D beta -lactamase, OXA-1. The oxa-31 gene was located on a ca. 300-kb nonconj ugative plasmid and on a class 1 integron, No additional efflux mechanism f or cefepime was detected in P. aeruginosa SOF-1, Resistance to cefepime and susceptibility to ceftazidime in P. aeruginosa were conferred by OXA-1 as well.