Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

Authors
Escobar, P Yardley, V Croft, SL
Citation
P. Escobar et al., Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice, ANTIM AG CH, 45(6), 2001, pp. 1872-1875
Citations number
33
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
6
Year of publication
2001
Pages
1872 - 1875
Database
ISI
SICI code
0066-4804(200106)45:6<1872:AOH(AA>2.0.ZU;2-1
Abstract
In both scid and BALB/e mouse-Leishmartia. donovani models, hexadecyphospho choline (miltefosine) and AmBisome had similar levels of activity. In contr ast, sodium stibogluconate (Pentostam) was significantly less active agains t L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmani al activity of miltefosine was similar in peritoneal macrophages derived fr om both scid and BALB/c mice, whereas Pentostam and AmBisome were significa ntly more active in the latter.