Citation
I. Sermet-gaudelus et al., Sputum itraconazole concentrations in cystic fibrosis patients, ANTIM AG CH, 45(6), 2001, pp. 1937-1938
Citations number
14
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804
→ ACNP
Volume
45
Issue
6
Year of publication
2001
Pages
1937 - 1938
Database
ISI
SICI code
0066-4804(200106)45:6<1937:SICICF>2.0.ZU;2-C
Abstract
Itraconazole diffusion in sputum was studied in 11 cystic fibrosis patients
,vith allergic bronchopulmonary aspergillosis. There was a high interindivi
dual variability in sputum itraconazole concentration and sputum/ serum dru
g concentration ratio. Three children had sputum drug concentrations before
oral administration that were lower than the itraconazole MIC at which 90%
of Aspergillus fumigatus strains were inhibited, although their serum drug
concentrations were within the therapeutic range.