Influence of hyperbranched multi-methacrylates for dental neat resins on proliferation of human gingival fibroblasts

We have previously shown that hyperbranched multi-methacrylate (H-MMA)-modi fied dental resins have VLC activities, lower polymerization shrinkage, and improved mechanical properties, compared to the 2,2-bis [4-(2-hydroxy-3-me thacryloyolxypropoxy)phenyl]propane/triethyleneglycol dimethacrylate (BisGM A/TEGDMA) neat resin. The results are due to the unique molecular structure and high molecular weight of H-MMA intermediates. The purpose of this stud y was to evaluate the biocompatibility of H-MMA-modified dental neat resins . The cell proliferation of three human gingival fibroblast strains or! eit her H-MMA, BisGMA/TEGDMA, or a polystyrene disk was examined. Following 10 days of cell proliferation, there was no statistical difference in cell num ber between H-MMA-modified and unmodified resin disks. H-MMA-modified resin s had less free monomer leaching than the unmodified resin but showed simil ar properties in water sorption and contact angle values. All these results suggest that the biocompatibility of H-MMA-modified dental neat resins is as good as that of commercially used BisGMA/TEGDMA resin and H-MMA has pote ntial applications in dental composites.