Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: Design of potent and specific 3,9-diazaspiro[5.5]undecanes

Authors
Smyth, MS Rose, J Mehrotra, MM Heath, J Ruhter, G Schotten, T Seroogy, J Volkots, D Pandey, A Scarborough, RM
Citation
Ms. Smyth et al., Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: Design of potent and specific 3,9-diazaspiro[5.5]undecanes, BIOORG MED, 11(10), 2001, pp. 1289-1292
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
10
Year of publication
2001
Pages
1289 - 1292
Database
ISI
SICI code
0960-894X(20010521)11:10<1289:SNGIAP>2.0.ZU;2-2
Abstract
The synthesis and biological activity of novel glycoprotein IIb-IIIa antago nists containing the 3,9-diazaspiro[5.5]undecane nucleus an described. The potent activity of these compounds as platelet aggregation inhibitors demon strates the utility of the spirocyclic structures as central template for n onpeptide RGD mimics. (C) 2001 Elsevier Science Ltd. All rights reserved.