Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: Design of potent antagonists containing the 3-azaspiro[5.5]undec-9-yl template

Authors
Pandey, A Seroogy, J Volkots, D Smyth, MS Rose, J Mehrotra, MM Heath, J Ruhter, G Schotten, T Scarborough, RM
Citation
A. Pandey et al., Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: Design of potent antagonists containing the 3-azaspiro[5.5]undec-9-yl template, BIOORG MED, 11(10), 2001, pp. 1293-1296
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
10
Year of publication
2001
Pages
1293 - 1296
Database
ISI
SICI code
0960-894X(20010521)11:10<1293:SNGIAP>2.0.ZU;2-5
Abstract
The synthesis and biological activity of novel glycoprotein IIb-IIIa anatag onists containing 3-azaspiro[5.5]undec-9-yl nucleus are described. The pote nt activity elf these compounds as platelet aggregation inhibitors demonstr ates the utility of the monoazaspirocyclic structure as central template fo r nonpeptide RGD mimics. (C) 2001 Elsevier Science Ltd. All rights reserved .