Pharmacological evaluation of a diarylmethylene-piperidine derivative: A new potent atypical antipsychotic?

Authors
Talaga, P Matagne, A Klitgaard, H
Citation
P. Talaga et al., Pharmacological evaluation of a diarylmethylene-piperidine derivative: A new potent atypical antipsychotic?, BIOORG MED, 11(10), 2001, pp. 1313-1316
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
10
Year of publication
2001
Pages
1313 - 1316
Database
ISI
SICI code
0960-894X(20010521)11:10<1313:PEOADD>2.0.ZU;2-X
Abstract
A new diaryl-methylene piperidine derivative, 2, displayed an atypical anti psychotic profile both in vitro and in vivo. The main pharmacological chara cteristics of this compound appears to reside in a more potent antagonism o f the 5-HT2 serotonergic receptor than of the D2 dopaminergic receptor. Thi s confirms that molecules displaying a D2/5-HT2 binding ratio <1 possess cl ozapine-like antipsychotic activity. (C) 2001 Elsevier Science Ltd. All rig hts reserved.