Rapid dephosphorylation of eIF4E by dietary protein in the skeletal muscleand liver of food-deprived rats

The effect of dietary protein on eIF4E phosphorylation mas examined in rats starved for 18 ii and then fed on either a 20% casein diet (20C) or a prot ein-free diet (OC). Refeeding with the 20C diet, hut not the OC diet, resul ted in partial dephosphorylation of eIF4E in both the skeletal muscle and l iver, The results suggest that the dephosphorylation of eIF-1E in response to food intake tvas regulated by the increase in plasma amino acid concentr ation that occurred after feeding with the 20C diet.