Soybean resistant proteins interrupt an enterohepatic circulation of bile acids and suppress liver tumorigenesis induced by azoxymethane and dietary deoxycholate in rats

Authors
Kanamoto, F Azuma, N Miyamoto, T Saeki, T Tsuchihashi, Y Iwami, K
Citation
F. Kanamoto et al., Soybean resistant proteins interrupt an enterohepatic circulation of bile acids and suppress liver tumorigenesis induced by azoxymethane and dietary deoxycholate in rats, BIOS BIOT B, 65(4), 2001, pp. 999-1002
Citations number
9
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
65
Issue
4
Year of publication
2001
Pages
999 - 1002
Database
ISI
SICI code
0916-8451(200104)65:4<999:SRPIAE>2.0.ZU;2-G
Abstract
The found that azoxymethane and dietary deoxycholate induced liver tumors i n rats. The incidence and the development of the tumor were closely related to the enterohepatic circulation of bile acids. The feeding of a high-mole cular-weight fraction of soy protein digest (HMF) suppressed the tumorigene sis, probably due to the inhibitory effect of soybean resistant protein an reabsorption of bile acids in the intestine.