We describe the incidence of cancer in The Gambia over a 10-year period usi
ng data collected through the Gambian National Cancer Registry. Major probl
ems involved with cancer registration in a developing country, specifically
in Africa are discussed. The data accumulated show a low overall rate of c
ancer incidence compared to more developed parts of the world. The overall
age standardized incidence rates (ASR) were 61.0 and 55.7 per 100 000 for m
ales and females, respectively. In males, liver cancer was most frequent, c
omprising 58% of cases (ASR 35.7) followed by non-Hodgkin lymphoma, 5.4% (A
SR 2.4), lung 4.0%, (ASR 2.8) and prostate 3.3% (ASR 2.5) cancers. The most
frequent cancers in females were cervix uteri 34.0% (ASR 18.9), liver 19.4
% (ASR 11.2), breast 9.2% (ASR 5.5) and ovary 3.2% (ASR 1.6). The data indi
cate that cancers of the liver and cervix are the most prevalent cancers, a
nd are likely to be due to infectious agents. It is hoped that immunization
of children under 1 year against hepatitis B will drastically reduce the i
ncidence of liver cancer in The Gambia. (C) 2001 Cancer Research Campaign.