High-grade lymphoma mimicking bone crisis in Gaucher's disease

A 33-year-old woman with type 1 Gaucher's disease developed painful swellin g of her right tibia. Initial diagnostics suggested a typical bone crisis. However, clinical course and subsequent imaging pointed to malignant diseas e, which was specified as high-grade lymphoma. Chemotherapy was applied tog ether with enzyme replacement and resulted in complete remission of the lym phoma. We conclude that osseous lesions, although suggestive of common mani festations of Gaucher's disease, should be discriminated very carefully fro m neoplastic infiltration to maintain curative treatment options.