Conversion of the carboxy group of sialic acid donors to a protected hydroxymethyl group yields an efficient reagent for the synthesis of the unnatural beta-linkage

Authors
Ye, XS Huang, XF Wong, CH
Citation
Xs. Ye et al., Conversion of the carboxy group of sialic acid donors to a protected hydroxymethyl group yields an efficient reagent for the synthesis of the unnatural beta-linkage, CHEM COMMUN, (11), 2001, pp. 974-975
Citations number
19
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
11
Year of publication
2001
Pages
974 - 975
Database
ISI
SICI code
1359-7345(2001):11<974:COTCGO>2.0.ZU;2-E
Abstract
New sialyl donors with a protected hydroxymethyl group at the anomeric cent er are over 1000 times more reactive than the normal ester containing sialy lation reagent and give excellent yield (> 90%) with unusually high beta -s tereoselectivity in sialylation.