The best structural model of ADH so far: a pyrazolylbis(thioimidazolyl)borate zinc ethanol complex

Authors
Seebacher, J Shu, MH Vahrenkamp, H
Citation
J. Seebacher et al., The best structural model of ADH so far: a pyrazolylbis(thioimidazolyl)borate zinc ethanol complex, CHEM COMMUN, (11), 2001, pp. 1026-1027
Citations number
19
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
11
Year of publication
2001
Pages
1026 - 1027
Database
ISI
SICI code
1359-7345(2001):11<1026:TBSMOA>2.0.ZU;2-5
Abstract
The new N,S,S ligand [HB(tim(o-An))(2)(pz(Ph,Me))](-) (L-1) was combined wi th zinc perchlorate and ethanol to form the complex [L-1.Zn(ethanol)]ClO4 w hich is the first zinc complex in which the N,S,S ligation of zinc and the attachment of ethanol occurring in the active center of horse liver alcohol dehydrogenase (ADH) have been reproduced; the structural details of the ZnN S2O coordination in the complex and in DMSO-inhibited ADH are in reasonably good agreement.