Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease

Citation
A. Andersson et al., Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease, CLIN CH L M, 39(3), 2001, pp. 229-233
Citations number
32
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
ISSN journal
14346621 → ACNP
Volume
39
Issue
3
Year of publication
2001
Pages
229 - 233
Database
ISI
SICI code
1434-6621(200103)39:3<229:HACPTR>2.0.ZU;2-6
Abstract
Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmona ry disease and in 29 healthy subjects. The purpose was to examine the influ ence of pro-oxidant activity caused by the lung disease on the metabolism o f homocysteine and other plasma thiols. We observed a decreased concentrati on of reduced glutathione and a decreased ratio of reduced/total glutathion e in the patients compared to the healthy individuals, which supports the h ypothesis of an association between free radicals and pathogenesis in some lung diseases. We also observed an increased total plasma homocysteine. The influence of a possible extracellular pro-oxidant activity on the concentr ation of total plasma homocysteine is discussed.