Frequency of celiac disease in individuals with Down syndrome in the United States

Authors
Mackey, J Treem, WR Worley, G Boney, A Hart, P Kishnani, PS
Citation
J. Mackey et al., Frequency of celiac disease in individuals with Down syndrome in the United States, CLIN PEDIAT, 40(5), 2001, pp. 249-252
Citations number
17
Categorie Soggetti
Pediatrics
Journal title
CLINICAL PEDIATRICS
ISSN journal
00099228 → ACNP
Volume
40
Issue
5
Year of publication
2001
Pages
249 - 252
Database
ISI
SICI code
0009-9228(200105)40:5<249:FOCDII>2.0.ZU;2-L
Abstract
Ninety-three individuals with Down syndrome (DS) were screened to investiga te the prevalence of celiac disease (CD) in the United States. Five of the 93 individuals were antiendomysial antibody (EMA) positive. Of the 5 who te sted positive for EMA, 4 were biopsied, 1 refused biopsy. Three of the 4 in dividuals biopsied manifested changes of CD on small bowel biopsy. This giv es a frequency of 3.2% of confirmed CD in our DS individuals and suggests t he need for periodic screening for celiac disease in this population.