On-line sample preparation for high throughput reversed-phase LC/MS analysis of combinatorial chemistry libraries

Authors
Tang, L Fitch, WL Smith, P Tumelty, D Cao, K Ferla, SW
Citation
L. Tang et al., On-line sample preparation for high throughput reversed-phase LC/MS analysis of combinatorial chemistry libraries, COMB CHEM H, 4(3), 2001, pp. 287-293
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
ISSN journal
13862073 → ACNP
Volume
4
Issue
3
Year of publication
2001
Pages
287 - 293
Database
ISI
SICI code
1386-2073(200105)4:3<287:OSPFHT>2.0.ZU;2-C
Abstract
An on-line sample preparation method utilizing a time-programmed autosample r is described for high throughput liquid chromatography/mass spectrometry (LC/MS). This approach is particularly helpful for the LC/MS analysis of sa mples which require solvents incompatible with HPLC in the sample preparati on process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.