DNA replication: Building the perfect switch

Authors
Diffley, JFX
Citation
Jfx. Diffley, DNA replication: Building the perfect switch, CURR BIOL, 11(9), 2001, pp. R367-R370
Citations number
30
Categorie Soggetti
Experimental Biology
Journal title
CURRENT BIOLOGY
ISSN journal
09609822 → ACNP
Volume
11
Issue
9
Year of publication
2001
Pages
R367 - R370
Database
ISI
SICI code
0960-9822(20010501)11:9<R367:DRBTPS>2.0.ZU;2-M
Abstract
a sophisticated molecular switch ensures that replication origins are activ ated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/ cyclosome is an important component of this switch.