Authors
Citation
Km. Ryan et al., Regulation and function of the p53 tumor suppressor protein, CURR OP CEL, 13(3), 2001, pp. 332-337
Citations number
66
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674
→ ACNP
Volume
13
Issue
3
Year of publication
2001
Pages
332 - 337
Database
ISI
SICI code
0955-0674(200106)13:3<332:RAFOTP>2.0.ZU;2-Q
Abstract
Loss of the p53 tumor suppressor pathway contributes to the development of
most human cancers. p53 is a nuclear protein that functions as a regulator
of transcription. Significant advances have been made recently in our under
standing of how p53 function is regulated and the mechanisms by which p53 m
ediates its effects.