Pregnancy and substance abuse

Substance abuse/dependence are common psychiatric disorders often associate d with other co-morbid diagnoses. These disorders are further complicated b y pregnancy. Our knowledge of the biology, diagnosis, treatment and prevent ion of substance abuse/dependence during pregnancy has evolved slowly over the past few decades. The mechanistic understanding of the consequences of prenatal substance exposure, driven by preclinical data, has advanced. Howe ver, clinical research advancing the treatment of this population has been limited, remaining generally dependent on retrospective, epidemiological, a nd survey-type data. Only recently has prospective pharmacological research in pregnant women been advocated. In the past year, reports of mechanistic actions, the use of pharmacotherapies, long-term outcome effects, risk fac tors, and the effectiveness of screening and treating licit and illicit dru g misuse during pregnancy have been published. Curr Opin Psychiatry 14:187- 193. (C) 2001 Lippincott Williams & Wilkins.