The functional Myosin Light Chain Kinase (MYLK) gene localizes with markerD3S3552 on human chromosome 3q21 in a > 5-Mb yeast artificial chromosome region and is not linked to olfactory receptor genes

Authors
Giorgi, D Brand-Arpon, V Rouquier, S
Citation
D. Giorgi et al., The functional Myosin Light Chain Kinase (MYLK) gene localizes with markerD3S3552 on human chromosome 3q21 in a > 5-Mb yeast artificial chromosome region and is not linked to olfactory receptor genes, CYTOG C GEN, 92(1-2), 2001, pp. 85-88
Citations number
10
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
92
Issue
1-2
Year of publication
2001
Pages
85 - 88
Database
ISI
SICI code
0301-0171(2001)92:1-2<85:TFMLCK>2.0.ZU;2-F
Abstract
The myosin light chain kinase (MYLK) gene is duplicated on human chromosome 3 (3q13 --> q21; 3p13), two sites known to contain olfactory receptor (OR) genes. The 3p13 site contains a MM-K pseudogene (MYLKP) associated with a cluster of OR pseudogenes and therefore could have arisen from the duplicat ion of a large region in 3q13 --> q21. Here, we present the localization of the MYLK gene in a >5-Mb region of the chromosome 3q21 integrated map. MYL K colocalizes with marker D3S3552. OR genes are absent from this region, su ggesting that the 3p13 duplicated region incurred further rearrangements du ring evolution. Copyright (C) 2001 S. Karger AG, Basel.