Isolation and initial characterization of the mouse Dnmt3/gene

Authors
Aapola, U Lyle, R Krohn, K Antonarakis, SE Peterson, P
Citation
U. Aapola et al., Isolation and initial characterization of the mouse Dnmt3/gene, CYTOG C GEN, 92(1-2), 2001, pp. 122-126
Citations number
15
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
92
Issue
1-2
Year of publication
2001
Pages
122 - 126
Database
ISI
SICI code
0301-0171(2001)92:1-2<122:IAICOT>2.0.ZU;2-X
Abstract
We have isolated and sequenced the mouse zinc finger gene, Dnmt3l (DNA cyto sine-5-methyltransferase 3-like), on mouse chromosome 10, showing similarit y to members of the DNMT3/Dnmt3 family. The Dnmt3l protein contains an ADD zinc finger. which Dnmt3l shares with Other Dnmt3 family members and Atrx. RT-PCR analysis showed Dnmt3l expression in testis, thymus, ovary, and hear t, as well as in 7-day, 15-day, and 17-day mouse embryos. Copyright (C) 200 1 S. Karger AG, Basel.