Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11 -> q13 imprinting clusters

Authors
Kelly, M Edgar, AJ Wevrick, R
Citation
M. Kelly et al., Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11 -> q13 imprinting clusters, CYTOG C GEN, 92(1-2), 2001, pp. 149-152
Citations number
10
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
92
Issue
1-2
Year of publication
2001
Pages
149 - 152
Database
ISI
SICI code
0301-0171(2001)92:1-2<149:AODRTO>2.0.ZU;2-U
Abstract
Identification of imprinted genes in the Prader-Willi/Angelman syndrome del etion region is complicated by the presence of large flanking repeats. Whil e inactive copies of DEXI are located within the repeats, we have now local ized the active DEXI gene to 15q11 --> q13 outside the PWS/AS deletion and Dexi to mouse chromosome 16, suggesting complex evolution of this genomic r egion in both species. Copyright (C) 2001 S. Karger AG, Basel.