Distribution of HOX genes in the chicken genome reveals a new segment of conservation between human and chicken

Homeobox genes play an important role in the regulation of early embryonic development. They represent a family of evolutionarily highly conserved tra nscription factors. In this work, several genes that belong to the four HOX gene clusters are assigned by in situ hybridization to four distinct chick en chromosomes. The four gene clusters are mapped to 2p2.1 (HOXA), 3q3.1 (H OXB), 1q3.1 (HOXC) and 7q1.3 --> q1.4 (HOXD). We confirm partial homologies already detected by genetic mapping between chicken chromosomes 1, 2 and 7 and human chromosomes 12, 7 and 2 and we describe a new conserved segment between chicken chromosome 3 and human chromosome 17. These results represe nt the first data that confirm the physical linkage between chicken HOX gen es and may improve our understanding of phylogenetic relationships and geno me evolution. Copyright (C) 2001 S. Karger AG, Basel.