A retro-inverso Prosaptide (TM) D5 promotes a myelination process in developing rats

Authors
Hiraiwa, M Campana, WM Wang, CY Otero, DAC O'Brien, JS
Citation
M. Hiraiwa et al., A retro-inverso Prosaptide (TM) D5 promotes a myelination process in developing rats, DEV BRAIN R, 128(1), 2001, pp. 73-76
Citations number
15
Categorie Soggetti
Neurosciences & Behavoir
Journal title
DEVELOPMENTAL BRAIN RESEARCH
ISSN journal
01653806 → ACNP
Volume
128
Issue
1
Year of publication
2001
Pages
73 - 76
Database
ISI
SICI code
0165-3806(20010531)128:1<73:ARP(DP>2.0.ZU;2-R
Abstract
The myelinotrophic action of Prosaptide((TM)) D5 was investigated in develo ping rats. Sulfatide concentrations in brain and sciatic nerve were determi ned to assess the development of myelination. Subcutaneous DS-injection sig nificantly increased sulfatide concentrations in both brain and sciatic ner ve by 250 and 150% over controls, respectively. D5 promoted ERK phosphoryla tion in iSC Schwann cells similar to prosaposin. The results showed that D5 treatment stimulated a myelination process in developing rat. (C) 2001 Els evier Science B.V. All rights reserved.