Wa. Gattis et al., A PROSPECTIVE, OPEN-LABEL STUDY OF SINGLE-DOSE CIPROFLOXACIN ABSORPTION AFTER CHEMOTHERAPY IN PATIENTS WITH MALIGNANCY, Pharmacotherapy, 17(4), 1997, pp. 836-840
The absorption of a single oral dose of ciprofloxacin 750 mg in patien
ts with cancer who had chemotherapy-induced Cancer and Leukemia Group
B grade I or II mucositis was evaluated. Ciprofloxacin was administere
d after an overnight fast. Plasma samples were collected before and 0.
5, 1, 1.5, 2, 3, 4, 6, 8, and 12 hours after the dose. Drug concentrat
ions were determined by reverse-phase high-performance liquid chromato
graphy with fluorescence detection. Pharmacokinetic values were charac
terized by noncompartmental methods. The mean +/- SD for area under th
e curve, mean peak concentration (C-max), and time to C-max (T-max) we
re 18.7 +/- 5.03 mg/L . hour, 4.41 +/- 1.74 mg/L, and 1.81 +/- 0.843 h
ours, respectively. The absorption of oral ciprofloxacin in patients w
ith chemotherapy-induced grade I or II mucositis compares with that in
healthy volunteers. These findings may call for further pharmacokinet
ic evaluation of the drug in a similar patient population.