A PROSPECTIVE, OPEN-LABEL STUDY OF SINGLE-DOSE CIPROFLOXACIN ABSORPTION AFTER CHEMOTHERAPY IN PATIENTS WITH MALIGNANCY

The absorption of a single oral dose of ciprofloxacin 750 mg in patien ts with cancer who had chemotherapy-induced Cancer and Leukemia Group B grade I or II mucositis was evaluated. Ciprofloxacin was administere d after an overnight fast. Plasma samples were collected before and 0. 5, 1, 1.5, 2, 3, 4, 6, 8, and 12 hours after the dose. Drug concentrat ions were determined by reverse-phase high-performance liquid chromato graphy with fluorescence detection. Pharmacokinetic values were charac terized by noncompartmental methods. The mean +/- SD for area under th e curve, mean peak concentration (C-max), and time to C-max (T-max) we re 18.7 +/- 5.03 mg/L . hour, 4.41 +/- 1.74 mg/L, and 1.81 +/- 0.843 h ours, respectively. The absorption of oral ciprofloxacin in patients w ith chemotherapy-induced grade I or II mucositis compares with that in healthy volunteers. These findings may call for further pharmacokinet ic evaluation of the drug in a similar patient population.