Sign of Leser-Trelat associated with adenocarcinoma of the rectum

The acute onset and/or rapid increase in size and number of multiple seborr heic keratoses associated with internal malignancy is called sign of Leser- Trelat. Although some authors reject its existence, there are more than 80 well-documented case reports in the literature. Here. we report a 75-year-o ld man who presented with abrupt appearance of multiple seborrheic keratose s without any suspicious symptom of cancer. The screening for malignant neo plasms let us detect a rectal adenocarcinoma that was in a curative stage. This case-report illustrates a true sign of Leser-Trelat, and proves that t hese patients must be appropriately investigated for underlying malignancy.