gamma-glutamyltransferase is a Helicobacter pylori virulence factor but isnot essential for colonization

Authors
McGovern, KJ Blanchard, TG Gutierrez, JA Czinn, SJ Krakowka, S Youngman, P
Citation
Kj. Mcgovern et al., gamma-glutamyltransferase is a Helicobacter pylori virulence factor but isnot essential for colonization, INFEC IMMUN, 69(6), 2001, pp. 4168-4173
Citations number
38
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
6
Year of publication
2001
Pages
4168 - 4173
Database
ISI
SICI code
0019-9567(200106)69:6<4168:GIAHPV>2.0.ZU;2-I
Abstract
The contribution of glutamyl transpeptidase (GGT) (gamma -glutamyltransfera se [EC 2. 3. 2. 2]) to Helicobacter pylori virulence nias investigated in p iglets and mice using GGT-deficient isogenic strains. All animals became co lonized. However, the bacterial load,vas significantly lower for mutant bac teria than for parent strains. These results suggest that GGT activity prov ides an advantage to H. pylori in colonization.