Pyrogenicity and cytokine-inducing properties of Streptococcus pyogenes superantigens: Comparative study of streptococcal mitogenic exotoxin Z and pyrogenic exotoxin A

Authors
Muller-Alouf, H Proft, T Zollner, TM Gerlach, D Champagne, E Desreumaux, P Fitting, C Geoffroy-Fauvet, C Alouf, JE Cavaillon, JM
Citation
H. Muller-alouf et al., Pyrogenicity and cytokine-inducing properties of Streptococcus pyogenes superantigens: Comparative study of streptococcal mitogenic exotoxin Z and pyrogenic exotoxin A, INFEC IMMUN, 69(6), 2001, pp. 4141-4145
Citations number
50
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
6
Year of publication
2001
Pages
4141 - 4145
Database
ISI
SICI code
0019-9567(200106)69:6<4141:PACPOS>2.0.ZU;2-U
Abstract
Streptococcal mitogenic exotoxin Z (SMEZ), a superantigen derived from Stre ptococcus pyogenes, provoked expansion of human lymphocytes expressing the V beta 2, 4, 7 and 8 motifs of T-cell receptor. SMEZ was pyrogenic in rabbi ts and stimulated the expression of the T-cell activation markers CD69 and cutaneous lymphocyte-associated antigen. A variety of cytokines was release d by human mononuclear leukocytes stimulated with SMEZ, which was 10-fold m ore active than streptococcal pyrogenic exotoxin A. Th2-derived cytokines w ere elicited only by superantigens and not by streptococcal cells.