Vaccination with Bordetella pertussis-pulsed autologous or heterologous dendritic cells induces a mucosal antibody response in vivo and protects against infection

Authors
George-Chandy, A Mielcarek, N Nordstrom, I Holmgren, J Eriksson, K
Citation
A. George-chandy et al., Vaccination with Bordetella pertussis-pulsed autologous or heterologous dendritic cells induces a mucosal antibody response in vivo and protects against infection, INFEC IMMUN, 69(6), 2001, pp. 4120-4124
Citations number
29
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
6
Year of publication
2001
Pages
4120 - 4124
Database
ISI
SICI code
0019-9567(200106)69:6<4120:VWBPAO>2.0.ZU;2-T
Abstract
This study demonstrates for the first time that vaccination with either aut ologous or heterologous dendritic cells CDC) pulsed with specific antigen i nduces protective immune responses against noninvasive bacteria, namely Bor detella pertussis. The DC-mediated protection is associated with strong B. pertussis-specific immunoglobulin G (IgG) and IgA responses in the lung.